However, the clinical manifestations of OA are found only in the 30% of OA diagnosed with radiological investigations [3]. The frequency between the two sexes varies according to age (OA in humans is more frequent under i 45 years while in the woman over i 55 years) and topographic distribution, as we have already seen, It is different[4].

OA is considered a disease multifactorial etiopathogenesis, triggered and carried forward by factors that change the state of joint balance. To maintain this balance is necessary, in the first place, the good health of the cartilage, structure necessary to cushion the load on the joints and to protect the bone ends from the friction they would encounter if they worked in direct contact with each other. A fundamental role therefore in the pathological process is played by the load to which the joints are subjected (therefore obesity is also among the risk factors for all the joints that are responsible for supporting the weight of the body against gravity). They also contribute mechanical factors such as joint instability, the traumas, the microtraumas, repeated mechanical stress due to professional activities (lumbarthrosis of drivers…) a sportswoman (coxarthrosis of professional dancers…). In the end, an important role is also played by genetic factors (that involve pathologies that compromise the metabolism or joint function, generating secondary OA: ochronosis, hemochromatosis, familial chondrocalcinosis, dysplasia, the Ehlers-Danlos syndrome, Marfan syndrome, etc.), metabolic disorders (es: diabetes mellitus, hyperuricemia), inflammatory processes, aging[5].